fosinopril sodium

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Related to fosinopril sodium: Monopril

fosinopril sodium

APO-Fosinopril (CA), Gen-Fosinopril (CA), Lin-Fosinopril (CA), Monopril, Novo-Fosinopril (CA), PMS-Fosinopril (CA), Ran-Fosinopril (CA), Ratio-Fosinopril (CA), Riva-Fosinopril (CA), Staril (UK)

🤔🤨😤 Pharmacologic class: Angiotensin-converting enzyme (ACE) inhibitor

🤔🤨😤 Therapeutic class: Antihypertensive

🤔🤨😤 Pregnancy risk category C (first trimester), D (second and third trimesters)


🤔🤨😤 Prevents conversion of angiotensin I to the vasoconstrictor angiotensin II, thereby reducing sodium and water retention and enhancing blood flow in circulatory system


🤔🤨😤 Tablets: 10 mg, 20 mg, 40 mg

Indications and dosages

🤔🤨😤 Hypertension

🤔🤨😤 Adults: 10 mg P.O. daily. May increase as required up to 80 mg/day; typical range is 20 to 40 mg P.O. daily.

🤔🤨😤 Heart failure

🤔🤨😤 Adults: 10 mg P.O. daily. May increase over several weeks up to 40 mg/day; typical range is 20 to 40 mg/day.

Dosage adjustment

🤔🤨😤 • Renal impairment

Off-label uses

🤔🤨😤 • Adjunct in myocardial infarction

🤔🤨😤 • Nephropathy


🤔🤨😤 • Hypersensitivity to drug or other ACE inhibitors

🤔🤨😤 • Angioedema (hereditary or idiopathic)

🤔🤨😤 • Pregnancy


🤔🤨😤 Use cautiously in:

🤔🤨😤 • aortic stenosis, cardiomyopathy, cerebrovascular or cardiac insufficiency, renal or hepatic impairment, hyponatremia, hypovolemia

🤔🤨😤 • black patients with hypertension

🤔🤨😤 • patients receiving diuretics concurrently

🤔🤨😤 • elderly patients

🤔🤨😤 • breastfeeding patients (safety not established)

🤔🤨😤 • children (safety not established).


🤔🤨😤 • Don't administer within 2 hours of antacids.

🤔🤨😤 • Give with or without food, but avoid giving with high-potassium foods or potassium supplements.

Adverse reactions

🤔🤨😤 CNS: dizziness, drowsiness, fatigue, headache, insomnia, weakness, vertigo

🤔🤨😤 CV: hypotension, angina pectoris, tachycardia

🤔🤨😤 EENT: sinusitis

🤔🤨😤 GI: nausea, vomiting, diarrhea, anorexia

🤔🤨😤 GU: proteinuria, erectile dysfunction, decreased libido, renal failure

🤔🤨😤 Hematologic: agranulocytosis, bone marrow depression

🤔🤨😤 Metabolic: hyperkalemia

🤔🤨😤 Respiratory: cough, bronchitis, dyspnea, asthma, eosinophilic pneumonitis

🤔🤨😤 Skin: rash, angioedema

🤔🤨😤 Other: altered taste, fever, hypersensitivity reactions including anaphylaxis


🤔🤨😤 Drug-drug.Allopurinol: increased risk of hypersensitivity reaction

🤔🤨😤 Antacids: decreased fosinopril absorption

🤔🤨😤 Antihypertensives, diuretics, general anesthetics, nitrates, phenothiazines: additive hypotension

🤔🤨😤 Cyclosporine, indomethacin, potassium-sparing diuretics, potassium supplements: hyperkalemia

🤔🤨😤 Digoxin, lithium: increased blood levels of these drugs, greater risk of toxicity

🤔🤨😤 Indomethacin: decreased hypotensive effects

🤔🤨😤 Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin, blood urea nitrogen, creatinine, potassium: increased levels

🤔🤨😤 Antinuclear antibody titer: false-positive result

🤔🤨😤 Sodium: decreased level

🤔🤨😤 Drug-food.Salt substitutes containing potassium: hyperkalemia

🤔🤨😤 Drug-herbs.Capsaicin: increased incidence of cough

🤔🤨😤 Drug-behaviors.Acute alcohol ingestion: additive hypotension

Patient monitoring

🤔🤨😤 • Monitor cardiovascular, respiratory, and neurologic status.

🤔🤨😤 • Monitor CBC and liver and kidney function tests.

🤔🤨😤 • Measure blood pressure to assess drug efficacy and detect hypotension.

🤔🤨😤 • Assess patient's potassium intake; monitor serum potassium level.

🤔🤨😤 Monitor for signs and symptoms of angioedema and anaphylaxis. If these occur, withdraw drug and contact prescriber immediately.

Patient teaching

🤔🤨😤 Instruct patient to immediately report rash or difficulty breathing.

🤔🤨😤 • Tell patient to report dizziness, fainting, bleeding tendency, change in urination pattern, swelling, or persistent cough.

🤔🤨😤 • Encourage patient to drink enough fluids to stay well hydrated.

🤔🤨😤 • Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

🤔🤨😤 • Instruct female patient to notify prescriber if she suspects she is pregnant.

🤔🤨😤 • Tell patient that he will undergo regular blood testing during therapy.

🤔🤨😤 • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved
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References in periodicals archive?
Fosinopril sodium is highly lipophilic (n-octanol/water ratio of 6.19 [6]), as well as the active form, fosinoprilat (log P = 3.70 [7]).
studied the properties of fosinopril sodium in aqueous media and demonstrated that the hydrophobic interactions create incentives for the occurrence of micellar aggregates, with a critical micelle concentration (cmc) of approximately 1.5 mg/mL, and with an average diameter of approximately 150 nm of the micellar aggregate, at concentrations above the cmc.
Fosinopril sodium was a gift sample from Terapia-Ranbaxy (Cluj-Napoca, Romania) and it was used without further purification.
[8] European Pharmacopoeia, Monograph of Fosinopril Sodium, vol.
Fosinopril sodium tablets are available in 10-, 20- and 40-mg strengths.